xCellSense®: Drug Resistance Profiling

Prove Activity Where Standard of Care Fails

Benchmark single-agent and combination activity in primary samples from patients with failure and relapsed/refractory disease — the population in which a new mechanism must demonstrate efficacy.

Test in the hardest population

Relapsed/refractory and SoC samples are where differentiation is most meaningful. We benchmark your compound(s) against standard-of-care activity in those same cells.

A male scientist looking through a microscope

What we measure

Activity benchmarking
Single-agent and combination activity versus standard of care in resistant samples.

Resistance mapping
Patterns of cross-resistance and retained sensitivity across the drug panel.

Restoration data
Quantitative evidence of whether your asset restores sensitivity.

Genotype linkage (optional)
Pair with NGS to link resistance phenotype to genotype.

Why it Matters

Resistant disease is the hardest test and the most persuasive proof — for go/no-go decisions, the salvage-combination rationale, and a differentiated development story.

Key Deliverables

01
Resistance map across the standard panel and your asset
02
Activity-restoration data in venetoclax- and SOC-failure samples
03
Benchmarking vs. standard of care in the same cells
04
Enrichment hypotheses for resistant-population strategy
05
Optional genotype-phenotype linkage via NGS with fast turnaround time
Let's Talk

Profile Your Drug Asset in Resistant / Relapsed Disease

A scientist — not a sales desk — will scope a tailored study and return a design and timeline.