Acute Myeloid Leukemia (AML)

Overcome lymphoma heterogeneity using functional data

xCellSense® quantifies drug sensitivity and combination synergy in primary NHL samples and profiles responders across lymphoma subtypes.

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AMLALLNHLMMMDS

The NHL development challenge

Non-Hodgkin lymphoma (NHL) is a heterogeneous group of diseases treated largely with multi-agent regimens. The key questions are which combinations work, in which subtypes, and which patients respond.

What we test in NHL

1

Combination design
sponsor asset alone and with CHOP-backbone and other agents, with pairwise synergy quantification

2

Responder profiling
Sensitivity scoringthat separates responders from non-responders

3

Subtype-resolved analysis
Response profiled across lymphoma subtypes

4

Optional genomics
Link mutational profile to functional response

Evidence in NHL

  • Our 2025 study in Biotechnology and Bioprocess Engineering quantified pairwise drug synergy among CHOP agents in 31 NHL patient samples and showed that combination sensitivity scores differentiated responders from non-responders.
  • Our EHA-SfPM 2024 poster predicted outcomes in treatment-naïve NHL using ex vivo drug-sensitivity testing.
Scientific Publications

Quantitative ex vivo assessment of chemotherapy synergy using patient-derived non-Hodgkin lymphoma samples

Biotechnology and Bioprocess Engineering
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Why it de-risks development

Defensible rationale for combination and responder enrichment across heterogeneous lymphoma subtypes.

Key Deliverables

01
Combination synergy across CHOP-backbone and custom regimens
02
Responder vs. non-responder scores from the combination sensitivity
03
Subtype-resolved profiling across lymphoma subtypes
04
Optional genotype l inkage via NGS
05
Interpretation and dataset with a fast turnaround time
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Scope an NHL Study on primary patient cells

A scientist — not a sales desk — will scope a tailored AML study and return a design and timeline.