xCellSense®: Immunotherapy Translational

Target, Engagement, and Killing — Measured in Patient Cells

For ADC, DAC, bispecific, and degrader programs: quantify antigen density, target engagement, and immune-mediated cytotoxicity (as confirmed for each program) directly in primary blood cancer-derived cells.

Built for target-dependent modalities*

Designed for ADCs, bispecifics / T-cell engagers, and targeted degraders — the modalities whose success depends on target expression and engagement in real patient cells.

* Not intended for cell- or gene-therapy products as the test article

A male scientist looking through a microscope

What we measure

Antigen-density quantification
By flow cytometry, gated on malignant vs. non-malignant populations

Target-engagement readouts
Receptor occupancy and target-protein degradation

Immune-mediated cytotoxicity (confirmed per program)
Killing-efficacy assays for bispecific and T-cell-engager candidates

Population resolution
Response and engagement resolved in the cell population that matters, not in the bulk well

Why it Matters

For target-dependent modalities, expression, engagement, and killing in real patient cells are the gating questions — answered before the clinic, on the xCellSense® platform.

Key Deliverables

01
Antigen-expression / density profiles by flow cytometry
02
Target-engagement PD readouts — receptor occupancy and target degradation
03
Immune-mediated cytotoxicity data for bispecific programs (confirmed per program)
04
Malignant- vs. -normal population resolution
05
Interpretation and dataset with a fast turnaround time
Let's Talk

Validate your biomarker

A scientist — not a sales desk — will scope a tailored study and return a design and timeline.