Our Science

xCellSense®:
Functional drug-response data from living patient cells

An ex vivo platform that measures how your compound behaves in real blood-cancer cells — integrating drug sensitivity, combination synergy, flow cytometry, NGS, and machine-learning analytics into a single workflow.

Scientist wearing a white lab coat and blue gloves using a pipette inside a laboratory biosafety cabinet.
The Hard Part, Solved

Keeping primary cells alive

Illustration of a mailer box filled with ImpriMed's proprietary transport media tubes

Primary blood-cancer cells are notoriously fragile outside the body. ImpriMed's proprietary Optimum Media preserves the viability and stability of patient-derived cells after biopsy — where conventional media lose them within days.

That viability window is what enables quantitative, reproducible functional testing on real patient cells. It is difficult to replicate — and it is the technical foundation of everything below.

One Sample, Multiple Readouts

Draw the readouts you need from a single sample

Dose-Response Package

Individual dose-response curves, IC₅₀ / AUC / Eₘₐₓ tables, and cross-sample statistics.

Drug Combination Package

Multi-drug combinations with quantitative synergy metrics (Bliss, Loewe, ZIP, HSA) and full dose-response data.

Flow Cytometry Package

Gating strategies, population viability, and antigen expression — resolving response in the malignant population.

Genomic & Transcriptomic

Targeted or full NGS — mutation summary, gene list, VAF, DEGs, and predicted impact.

Integration Summary

Responder stratification, biomarker and clinical insights, and inclusion-criteria recommendations.

Extended Analyses

scRNA-seq (UMAP, pathway, cluster markers) and bulk RNA-seq / Methyl-seq integration.

From Sample to Decision

A defined 6-step process

01
Study Design
02
Procurement & QC
03
Plate Setup & Treatment
04
Readout
05
Analysis
06
Reporting

* Every study is custom-designed for your candidates, controls, dose ranges, readouts, and statistical analysis.

Machine-learning Analytics

A clear, defensible interpretation — not a raw-data dump

An ML analytics layer scores synergy, classifies response patterns, extracts predictive biomarkers, and stratifies responders from non-responders — transforming multidimensional functional and genomic data into a sponsor-ready interpretation.

ImpriMed uses multimodal AI to improve treatment outcomes
Peer-Reviewed Evidence

Published, not marketed

Scientific Publications
Haematologica

Prognostic value of European LeukemiaNet 2022 criteria and genomic clusters using machine learning in older adults with acute myeloid leukemia

Haematologica
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Scientific Publications
Blood Research Journal Logo

Recent advances in and applications of ex vivo drug sensitivity analysis for blood cancers

Blood Research
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Scientific Publications
Biotechnology and Bioprocess Engineering

Quantitative ex vivo synergy profiling uncovers heterogeneous combination responses in acute myeloid leukemia

Biotechnology and Bioprocess Engineering
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Presentations
ASH

Quantitative ex vivo synergy profiling uncovers heterogeneous combination responses in AML primary samples

67th ASH Annual Meeting and Exposition
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Presentations
ASH Logo

Ex vivo drug sensitivity testing in Korean AML patients: Integration of functional and genomic profiles for predicting clinical response and survival

67th ASH Annual Meeting and Exposition
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Presentations
ASH

Prognostic Utility of the Patient-Derived AML Cells' Ex Vivo Drug Sensitivity Results

65th ASH Annual Meeting and Exposition
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Diagram of xCellSense platform
Let's Talk

Discuss how xCellSense® applies to your program

A scientist — not a sales desk — will scope a tailored study on primary patient cells.